The Lions will be looking to make it two from two in the EPCR Challenge Cup when they take on Top 14 outfit Perpignan this Saturday at 19:30 (SA Time) in Round 4 of the competition.
A bonus-point win for the Johannesburg franchise would boost their chances of entering the Round of 16 of the European competition.
In the backline, Junior Springbok Haashim Pead starts at halfback, with explosive centre Henco van Wyk occupying the inside centre position. Also back is winger Eduan Keyter.
Up front, only Eddie Davids, Renzo du Plessis and captain Francke Horn are kept in the starting line-up.
Lions: 1. Eddie Davids, 2. Morne Brandon, 3. RF Schoeman, 4. Etienne Oosthuizen, 5. Reinhard Nothnagel, 6. Renzo du Plessis, 7. Batho Hlekani, 8. Francke Horn (c), 9. Haashim Pead, 10. Chris Smith, 11. Angelo Davids, 12. Henco van Wyk, 13. Erich Cronje, 14. Eduan Keyter, 15. Quan Horn. Replacements: 16. Franco Marais, 17. SJ Kotze, 18. Conraad van Vuuren, 19. Ruben Schoeman, 20. Darrien Landsberg, 21. Siba Mahashe, 22. Nico Steyn, 23. Bronson Mills.