Italy head coach Gonzalo Quesada has made seven changes to the starting XV that beat Namibia 73-6 last Friday. The Springboks will host Italy at Loftus Versfeld on Saturday at 17:10 (SA Time).
There is a new-look back three and centre pairing, while Lorenzo Cannone starts at No 8 in a reshuffled loose trio.
Italy: 15 Jacopo Trulla, 14 Louis Lynach, 13 Tommaso Menoncello, 12 Marco Zanon, 11 Simone Gesi, 10 Giacomo De Re, 9 Alessandro Fusco, 8 Lorenzo Cannone, 7 Manual Zuliani, 6 Alessandro Izekor, 5 Andrea Zambonini, 4 Niccolo Cannone (c), 3 Simone Ferrari, 2 Tommasso Di Bartolomeo, 1 Danilo Fischetti. Replacements: 16 Pablo Dimcheff, 17 Mirco Spagnolo, 18 Muhamed Hasa, 19 Matteo Canali. 20 Ross Vintcent, 21 David Odiase, 22 Alessandro Garbisis, 23 Giulo Bertaccinini