Head coach Steve Borthwick has named his team to face South Africa at Allianz Stadium on Saturday 16 November.
Four changes to the starting side that were narrowly beaten by Australia last weekend, as Ollie Sleightholme, Jack van Poortvliet, Freddie Steward, and Sam Underhill all come into the team.
Jamie George will captain England, once again supported by four vice-captains: Maro Itoje, Ben Earl, Ellis Genge, and George Ford. Wing Tom Roebuck is included among the replacements for the first time this autumn.
“We're excited to challenge ourselves against the world's top-ranked team and back-to-back Rugby World Cup champions,” said Borthwick. “Test matches against South Africa are always thrilling contests, and I'm sure Saturday will be no exception.”
England: 15 Freddie Steward, 14 Tommy Freeman, 13 Ollie Lawrence, 12 Henry Slade, 11 Ollie Sleightholme, 10 Marcus Smith, 9 Jack van Poortvliet, 8 Ben Earl, 7 Sam Underhill, 6 Chandler Cunningham-South, 5 George Martin, 4 Maro Itoje, 3 Will Stuart, 2 Jamie George (captain), 1 Ellis Genge. Replacements: 16 Luke Cowan-Dickie, 17 Fin Baxter, 18 Dan Cole, 19 Nick Isiekwe, 20 Alex Dombrandt; 21 Harry Randall, 22 George Ford, 23 Tom Roebuck.