| Results Week Ending - 29 May 2022 | ||
| 1stXV | ||
| Central Region | ||
| Duineveld | 12-19 | Diamantveld |
| Goudveld | 00-44 | Welkom Gim |
| Grey College | 41-17 | Monnas |
| Sand du Plessis | 33-17 | Hendrik Potgieter |
| Upington | 20-20 | Noord Kaap |
| Eastern Cape | ||
| Cambridge | 06-19 | Stirling |
| Graeme College | 22-17 | Kingswood |
| Selborne | 10-19 | Queen's College |
| St Andrew's | 05-40 | Grey High |
| KwaZulu Natal | ||
| Clifton | 24-17 | Kearsney |
| DHS | 33-23 | Westville |
| Maritzburg College | 11-30 | Hilton |
| St Charles | 08-18 | Northwood |
| Noordvaal | ||
| Affies | 35-17 | Jeppe |
| Alberton | 28-12 | Bracken High |
| Alan Glenn | 48-10 | Queens High |
| Bastion | 44-12 | Jan Viljoen |
| Merensky | 49-33 | Ben Viljoen |
| Ben Vorster | 15-31 | Kempton Park |
| Benoni High | 19-22 | Heronbridge |
| Carleton Jones | 58-00 | Elsburg |
| Carletonville | 60-00 | Bracken High |
| Carletonville | 29-19 | Bekker |
| Centurion | 41-34 | Alberton |
| Cornwall Hill | 51-07 | Potch Boys High |
| Curro Heuwelkruin | 07-44 | Frans du Toit |
| De La Salle | 33-24 | Rooseveldt |
| Die Anker | 57-14 | Dr Malan |
| Dinamika | 29-33 | Florida |
| Driehoek | 07-42 | Brandwag |
| EG Jansen | 34-26 | Waterkloof |
| Ermelo | 44-26 | Rob Ferreira |
| Ermelo | 15-39 | Piet Retief |
| Fochville | 24-10 | Linden |
| Hartbeespoort | 08-36 | Brits |
| Helpmekaar | 46-27 | Middelburg HTS |
| Heronbridge | 22-19 | Benoni |
| Hugenote Springs | 46-12 | Heidelberg Volkies |
| Jeugland | 07-60 | Klerksdorp |
| King David | 44-03 | Fourways |
| Krugersdorp | 26-22 | Trinityhouse |
| Leeuwenhof | 39-03 | Hans Moore |
| Lichtenburg | 37-28 | Eldoraigne |
| Linden | 11-00 | Roodepoort |
| Louis Trichardt | 33-08 | Nylstroom |
| Marais Viljoen | 07-73 | Garsfontein |
| Menlopark | 23-33 | Noordheuwel |
| Middelburg | 40-24 | Rustenburg |
| Midstream | 34-25 | Pretoria Noord |
| Nelspruit | 38-14 | Montana |
| Oos Moot | 26-18 | Ligbron |
| Parktown | 19-19 | St Stithians |
| Piet Retief | 36-22 | Witbank HTS |
| Pretoria Boys High | 79-00 | St David's |
| Queens High | 38-22 | Alberton |
| Randburg | 28-11 | St Benedict's |
| Secunda | 31-17 | Pietersburg |
| St Alban's | 18-32 | KES |
| St Peter's | 49-00 | King David Victory Park |
| Standerton | 15-13 | Oosterland |
| Tom Naude HTS | 38-05 | Piet Potgieter |
| Transvalia | 68-00 | Zwartkop |
| Western Cape | ||
| Bellville Suid | 24-03 | Westerford |
| Camps Bay | 38-05 | Tableview |
| Charlie Hofmeyer | 72-05 | Stellenbosch |
| Edgemead | 06-33 | Bosmansdam |
| Hottentots Holland | 14-00 | Bellville HTS |
| Jan van Riebeeck | 13-12 | President |
| Langenhoven Gim | 10-12 | Swartland |
| Melkbosstrand | 55-00 | Sentraal |
| Oakdale | 00-10 | Outeniqua |
| Paarl Boishaai | 29-07 | Bishops |
| Parel Vallei | 26-17 | Bellville |
| Piketberg | 12-10 | Schoonspruit |
| SACS | 22-23 | Durbanville |
| Stellenberg | 50-11 | Brackenfell |
| Strand | 91-12 | Kasselsvlei |
| Swartland | 12-10 | Langenhoven Gim |
| Swellendam | 24-07 | Bonnievale |
| Wynberg | 24-15 | Rondebosch |