| Results Week Ending - 24 July 2022 | ||
| 1stXV | ||
| Central Region | ||
| Diamantveld | 19-22 | Witteberg |
| Goudveld | 17-27 | Jim Fouche |
| Noord Kaap | 12-36 | Fichardpark |
| Retief/Kestell | 15-05 | Ladybrand |
| Voortrekker Beth | 40-17 | Fichardtpark |
| Voortrekker Beth | 32-10 | Sentraal |
| Vrede | 50-14 | Ficksburg |
| Eastern Cape | ||
| Brandwag | 57-12 | Itembelihle |
| Cambridge | 05-12 | Westering |
| Dale College | 40-00 | Stirling High |
| Framesby | 14-10 | Grey High |
| Graeme College | 24-10 | Pearson |
| Grens | 10-27 | Queen's College |
| Kingswood | 17-21 | Nico Malan |
| Otto du Plessis | 27-05 | DF Malherbe |
| Selborne | 27-26 | Hudson Park |
| St Andrew's | 20-20 | Marlow |
| KwaZulu-Natal | ||
| DHS | 27-20 | Kirkham Grammar |
| Glenwood | 54-13 | Northwood |
| Maritzburg College | 12-29 | Affies |
| Noordvaal | ||
| Brandwag (Benoni) | 26-10 | Oosterlig |
| Die Anker | 52-06 | Centurion |
| Die Wilger | 33-25 | CR Swart |
| Florida | 45-12 | Randburg |
| Fochville | 33-22 | Bastion |
| Frans du Toit | 26-15 | Curro Heuwelkruin |
| Garsfontein | 34-10 | Helpmekaar |
| Jeugland | 24-29 | Hugenote (Springs) |
| Klerksdorp | 29-25 | Eldoraigne |
| Ligbron | 18-14 | Heidelberg Volkies |
| Marais Viljoen | 34-47 | Monnas |
| Menlopark | 23-19 | EG Jansen |
| Merensky | 20-12 | Frikkie Meyer |
| Middelburg | 52-19 | Kempton Park |
| Midstream | 26-19 | Pretoria North |
| Montana | 29-19 | Zwartkop |
| Montana | 17-15 | Oos Moot |
| Oos Moot | 24-24 | Lichtenburg |
| Overkruin | 24-13 | John Vorster HTS |
| Parktown | 07-38 | Jeppe |
| Potch Gimmies | 19-31 | Wagpos |
| Potch Volkies | 31-13 | Alberton |
| Pretoria Boys High | 14-17 | KES |
| Rustenburg | 28-33 | Nelspruit |
| Secunda | 17-16 | Wesvalia |
| Transvalia | 11-15 | Trio |
| Waterkloof | 27-27 | Noordheuwel |
| Wonderboom | 10-05 | Overkruin |
| Western Cape | ||
| Bellville | 33-43 | Durbanville |
| Boland Landbou | 13-29 | Rondebosch |
| Charlie Hofmeyer | 27-10 | Hugenote |
| Curro Langebaan | 28-17 | Vredendal |
| Edgemead | 18-16 | Bergvliet |
| Hopefield | 17-12 | Strand |
| Hopefield | 05-08 | DF Malan |
| Hottentots Holland | 08-24 | Primrose RFC |
| Labori | 27-25 | Hopefield |
| Langenhoven Gim | 36-08 | Eden HTS |
| Melkbosstrand | 10-17 | DF Malan |
| Melkbosstrand | 26-21 | Tygerberg |
| Melkbosstrand | 35-12 | Kasselsvlei |
| Montagu | 21-17 | Overberg |
| Oakdale | 22-20 | Drostdy HTS |
| Paarl Gim | 57-26 | Bishops |
| Parel Vallei | 07-27 | Worcester Gym |
| Paul Roos | 32-17 | Wynberg |
| Roberson | 53-00 | Stellenbosch |
| SACS | 11-33 | Boishaai |
| Stellenberg | 27-17 | Outeniqua |
| Strand | 17-22 | Swartland |