The organisers will after assessing all the teams' performances on day one decide on the fixtures for day 2 and day 3 to ensure strength vs strength match-ups every day.
| Date | SA Time | Competition | Venue | Home Team | Away Team | |
| 26-Mar-22 | 08h45 | Oakdale Rugby Week | Populiersbos | Landboudal | vs | Montagu |
| 26-Mar-22 | 08h45 | Oakdale Rugby Week | De Eike | Ellisras | vs | Swartland |
| 26-Mar-22 | 09h55 | Oakdale Rugby Week | De Eike | Brackenfell | vs | Jeugland |
| 26-Mar-22 | 09h55 | Oakdale Rugby Week | Populiersbos | Strand | vs | Oos Moot |
| 26-Mar-22 | 09h55 | Oakdale Rugby Week | De Tuine | Vredendal | vs | Westering |
| 26-Mar-22 | 11h05 | Oakdale Rugby Week | De Eike | Potch Gim | vs | Hugenote |
| 26-Mar-22 | 11h05 | Oakdale Rugby Week | Populiersbos | Merensky | vs | Augsburg |
| 26-Mar-22 | 12h15 | Oakdale Rugby Week | Populiersbos | Vryburg | vs | Oudtshoorn |
| 26-Mar-22 | 12h15 | Oakdale Rugby Week | De Eike | Oosterlig | vs | Robertson |
| 26-Mar-22 | 14h00 | Oakdale Rugby Week | Populiersbos | Overberg | vs | Volkies Graaff-Reinette |
| 26-Mar-22 | 14h00 | Oakdale Rugby Week | De Eike | Lichtenburg | vs | Upington |
| 26-Mar-22 | 15h10 | Oakdale Rugby Week | De Eike | Hermanus | vs | Alberton |
| 26-Mar-22 | 15h10 | Oakdale Rugby Week | Populiersbos | Parel Vallei | vs | Bredasdorp |
| 26-Mar-22 | 16h20 | Oakdale Rugby Week | De Eike | Zwartkop | vs | Pearson |
| 26-Mar-22 | 16h20 | Oakdale Rugby Week | Populiersbos | Sentraal | vs | Langenhoven Gim |
| 26-Mar-22 | 18h00 | Oakdale Rugby Week | De Eike | Kempton Park | vs | Brandwag (Uitenhage) |
| 26-Mar-22 | 19h10 | Oakdale Rugby Week | De Eike | Rustenburg | vs | Diamantveld |