Tom Curry (Sale Sharks, England), Josh Navidi (Cardiff Rugby, Wales) and Adam Beard (Ospreys, Wales) will make their Lions debuts on Wednesday evening when the tourists take on Cell C Sharks at Emirates Airline Park (kick off 7pm).
Ireland lock, Iain Henderson (Ulster Rugby, Ireland), will captain the Lions for the first time, while Tour Captain, Conor Murray (Munster Rugby, Ireland), is named amongst the replacements.
This will be the second of eight Tour matches in the 2021 Castle Lager Lions Series which culminates with three Tests against World Champions, the Springboks.
“It’s a quick turnaround from Saturday, but we’ll be ready to go by Wednesday night,” said Lions Head Coach Warren Gatland.
“I’m pleased we managed to come through the weekend’s game unscathed, and the boys have rested and recovered well. We feel like we’re slowly building, but, as ever, there’s still room for improvement in all facets of our game.
“Wednesday night is another chance for us to have a look at a few more combinations. I’m looking forward to seeing how the back row goes; it’s an exciting mixture and one that we hope will offer something a bit different.
“We expect another physical test against a side who are known for their power play and ambition.
“My congratulations to Tom, Josh and Adam ahead of their first starts in a Lions jersey.”
The Lions opened their 2021 Castle Lager Lions Series with an eight-try victory over Sigma Lions.
B&I Lions: 15. Liam Williams, 14. Anthony Watson, 13. Elliot Daly, 12. Bundee Aki, 11. Duhan van der Merwe, 10. Dan Biggar, 9. Gareth Davies, 8. Sam Simmonds, 7. Tom Curry, 6. Josh Navidi, 5. Adam Beard, 4. Iain Henderson (C), 3. Zander Fagerson, 2. Luke Cowan-Dickie, 1. Mako Vunipola. Replacements: 16. Ken Owens, 17. Rory Sutherland, 19. Tadhg Beirne, 20. Jack Conan, 21. Conor Murray, 22. Stuart Hogg, 23. Chris Harris.