Stormers head coach John Dobson made two injury-forced changes to the starting team, which did duty last week and both come in the forward pack with hooker Bongi Mbonambi and skipper Siya Kolisi both ruled out.
Scarra Ntubeni is set to play in the front row in between Malherbe in his 100th game and new skipper Steven Kitshoff, while Johan du Toit starts in the back row at No.8 alongside his brother Pieter-Steph.
There are four changes among the replacements, with Cobus Wiese, Juarno Agustus and Jean-Luc du Plessis returning from injury and Chad Solomon set to make his first appearance of the season.
DHL Stormers: 15 Dillyn Leyds, 14 Sergeal Petersen, 13 Ruhan Nel, 12 Jamie Roberts, 11 Seabelo Senatla, 10 Damian Willemse, 9 Herschel Jantjies, 8 Johan du Toit, 7 Pieter-Steph du Toit, 6 Jaco Coetzee, 5 Chris van Zyl, 4 Salmaan Moerat, 3 Frans Malherbe (100th DHL Stormers cap), 2 Scarra Ntubeni, 1 Steven Kitshoff. Replacements: 16 Chad Solomon, 17 Ali Vermaak, 18 Wilco Louw, 19 Cobus Wiese, 20 Ernst van Rhyn, 21 Juarno Augustus, 22 Godlen Masimla, 23 Jean-Luc du Plessis.